Gardaí have seized cocaine and cannabis with a street value of more than €2.1 million following searches.
Officers from the Garda National Drugs and Organised Crime Bureau also recovered more than €112,000 in cash following searches in Kildare and Westmeath on Saturday.
The operation, which targeted transnational organised crime, was supported by a number of national units and personnel from the Eastern Region and led to the arrest of five men and one woman.
During an initial search, gardai seized approximately 29kg of suspected cocaine with an estimated street value of around two million euros and 112,050 euros in cash.
As part of follow-up searches, a pill manufacturing facility was discovered containing two pill-making machines.
Cannabis with an estimated street value of €125,000 was seized along with other drug paraphernalia.
A cannabis cultivation facility was also discovered.
Two men have been charged with drug-related offences and are due to appear before Naas District Court on Monday.
Another man and woman have since been released without charge pending a file to the Director of Public Prosecutions.
Two other men remain in Garda custody.
Assistant Commissioner Justin Kelly said: “I commend the detectives involved in this successful operation to disrupt an organised criminal group exploiting our communities.
“This work shows our absolute determination to target the activities of key individuals involved in the production and distribution of controlled drugs.
“Illicit pill manufacturing is undertaken in dangerous clandestine facilities with no control measures whatsoever in place, adding to the risk to end users.”
Meanwhile, a man in his 30s is due to appear before the Criminal Courts of Justice in Dublin on Monday after gardai seized an estimated 65,000 euros in combined drugs and 9,180 euros in cash following searches in north Dublin on Friday.