Common gut bacteria may contribute to bowel cancer, scientists say

A toxin released by E.coli causes a “distinctive pattern of DNA damage in bowel cancer”.
A toxin released by E.coli causes a “distinctive pattern of DNA damage in bowel cancer”.

A common type of bacteria found in the gut may play a role in the development of bowel cancer, according to research.

Scientists have found a toxin released by a strain of the E.coli bacteria leaves unique patterns, or “fingerprints”, as it damages the DNA in the cells lining the gut.

These so-called fingerprints were observed mainly in bowel cancer tumours, showing “a direct link” between the microbial toxin and the genetic changes that contribute to cancer development.

The researchers suggested that detecting this specific DNA damage could, in future, allow doctors to identify people at higher risk of the disease.

Professor Hans Clevers, of the Hubrecht Institute in the Netherlands and one of the study authors, said: “Things like tobacco or UV light are known to cause specific patterns of DNA damage, and these fingerprints can tell us a lot about past exposures that may have caused cancer to start.

“But this is the first time we’ve seen such a distinctive pattern of DNA damage in bowel cancer, which has been caused by a bacterium that lives in our gut.”

The scientists investigated the role of gut microbiome, or the ecosystem of bacteria in the digestive system, in the development of bowel cancer.

They focused on a strain of E. coli producing the toxin known as colibactin.

Miniature replicas of the gut grown in the lab were exposed to this toxin and the researchers found evidence of DNA damage following unique patterns.

The team analysed the DNA sequences of more than 5,500 tumour samples and found these fingerprints to be present more often in bowel cancers than other types of tumour.

The researchers then focused on bowel tumours specifically, looking at more than 2,000 samples collected as part of the 100,000 Genomes Project run by Genomics England.

They found the colibactin fingerprints were present in 4% to 5% of the samples, which the researchers said suggests that colibactin-producing E. coli may contribute to 1 in 20 bowel cancer cases in the UK.

They are now looking at other bacteria and their toxins associated with bowel cancer as part of the next steps in their research.

Professor Philip Quirke, of the University of Leeds and study-co-author, said: “We hope to identify more DNA damage fingerprints to paint a better picture of risk factors.

“We will then need to work out how we can reduce the presence of high-risk bacteria in the gut.

“But this is all in the future, so for now people should continue to eat a healthy diet and participate in bowel cancer screening.”

There are around 42,000 new bowel cancer cases every year in the UK, where it remains the second most common cause of cancer death, according to Cancer Research UK.

The research, funded by a £20 million Cancer Research UK Grand Challenge award, is published in the journal Nature.