Taoiseach Leo Varadkar plans to speak to the family of the teenager who suffered a "very violent assault" in Co Meath earlier this week.
Footage of the Monday afternoon attack in Navan has been widely shared on social media, with speculation that it was motivated by homophobia.
Gardaí have yet to make any arrests in connection with the assault.
A juvenile attended Our Lady of Lourdes Hospital in Drogheda following the incident, where he received treatment for serious facial injuries.
Both the victim of the assault and the alleged perpetrators are understood to be students in Navan.
Their school has not responded to queries about potential expulsions linked to the incident.
"I'm really appalled at what we saw happening in Navan there the other day, it seems to me that young man was targeted, essentially because he's different, and was subjected to a very violent assault," Mr Varadkar said.
"And what's worse still is people felt the need to video it, and then put online, it takes a particular type of person to post pictures and videos of people with the purpose of humiliating them, a particularly nasty type of individual does that type of thing.
"And then to see bystanders not only not trying to help, but actually joining in. So it was particularly hard to watch."
He extended his sympathies go to the young man and his family, and said he planned to contact the family, confirming that Justice Minister Simon Harris has already spoken to them.
"I think there is a real issue here with parental responsibility," he said.
"Those young people are easily identified – those parents know who they are and they need to act and take responsibility for this as well."
Tanaiste Micheál Martin described the incident as "stomach-churning" and accused social media companies of "not doing enough" to remove violent bullying content.
Speaking during leaders' questions in the Dáil on Thursday, Mr Martin said: "I think the country is sickened and very disturbed by this shocking attack on this young boy.
"The random violent nature of it, the videoing of it and the posting of the video online."
He said there had been increased violence against the LGBT+ community in Ireland.
The Fianna Fáil leader was responding to a question from Sinn Féin TD Pearse Doherty, who described the attack as "sickening".
Mr Doherty said he was "utterly disgusted and sickened to the core" to see the "unprovoked attack on a young child 14 years of age" which was shared on Twitter.
"There's no room in our society for this type of behaviour, for this type of violence, for this type of bullying," he said.
Aontú leader and West Meath TD Peadar Tóibín said voiced solidarity with the teenager and his family.
"This child was brutally and senselessly attacked on the way home from school causing great damage – the videoing and the sharing on social media has also done damage to this child," he said.
"I would ask people not to blame the school for these actions – this is a societal problem."
