Bill Cosby’s 44-year-old daughter Ensa Cosby has died, according to a spokesman for the comedian.
Andrew Wyatt confirmed that Ms Cosby died in Massachusetts from renal disease but provided no other details.
In a statement, Mr Wyatt asked for prayers for the Cosby family and that the family be given peace at this time.
Cosby lost another child in 1997 when his son Ennis was shot dead during a robbery attempt in Los Angeles.
Ensa Cosby appeared on one episode of The Cosby Show, which ran from 1984 to 1992.
Cosby, 80, owns a home in the western Massachusetts town of Shelburne Falls.
Ms Cosby spoke out on her father’s behalf before his trial last year on charges he drugged and molested a woman at his suburban Philadelphia home in 2004.
He has pleaded not guilty and remains free on bail. His first trial ended with a hung jury last year.
Ms Cosby and her sister Erinn recorded statements that aired on New York hip hop radio station Power 105. She Cosby said she strongly believed in her father’s innocence and believed racism played a big role in aspects of the scandal.
“How my father is being punished by a society that still believes black men rape white women but passes off ‘boys will be boys’ when white men are accused, and how the politics of our country prove my disgust. My father has been publicly lynched in the media,” she said.
A defamation lawsuit filed by seven women who have accused Cosby of sexual misconduct is also pending in Massachusetts.
