Takotsubo syndrome: How you really can potentially die of a broken heart

You really can die of a broken heart: Takotsubo syndrome, which is triggered by extreme emotional or physical stress, is often mistaken for a heart attack. Lisa Salmon finds out more

Takotsubo syndrome causes a weakening of the left ventricle, the heart's main pumping chamber, usually after severe emotional or physical stress, for example a bereavement

IF YOU thought dying from a broken heart was just an old romantic cliche, think again – it can actually be a medical condition which, in some cases, can be fatal.

'Broken heart' syndrome, or Takotsubo syndrome, can be brought on by extreme emotional stress, sometimes resulting in heart failure. It's only relatively recently that it has been recognised as a condition and is still thought to be under-diagnosed as it is often mistaken for a heart attack – the symptoms can be very similar.

"It's difficult to put a figure on how many people are affected by Takotsubo syndrome because it's only been widely recognised in the last few years, but research suggests it could represent 6-7 per cent of all presumed heart attacks admitted through a cardiology department," says Emily McGrath, a senior cardiac nurse at British Heart Foundation (BHF).

Here, McGrath explains more about 'broken heart syndrome'...

:: What is Takotsubo syndrome?

The syndrome causes a weakening of the left ventricle, the heart's main pumping chamber, usually after severe emotional or physical stress. The ventricle changes shape and enlarges to resemble a Japanese octopus pot, a 'takotsubo', which has a narrow neck and a round bottom (the condition was first officially reported in Japan in 1990), and stops the heart from pumping properly.

:: What causes it?

The BHF says three-quarters of people diagnosed with Takotsubo syndrome, which is also known as Takotsubo cardiomyopathy or stress cardiomyopathy, will have recently experienced either significant emotional or physical stress.

As well as bereavement, stresses associated with Takotsubo syndrome include severe pain, surgery, overwhelming fear and receiving extremely bad news, although there have also been reports of people getting it after the shock of intense, unexpected happiness, such as winning the lottery. Exactly why some people's react in this way is still a mystery.

One theory, suggested by researchers at Imperial College London, is that the syndrome is a result of body changing its response to the high level of adrenaline released during periods of extreme stress.

Normally, the body reacts to adrenaline by stimulating the heart in preparation for a 'fight or flight' response, increasing oxygen levels in the body. Conversely, in Takotsubo patients, stress hormones may cause changes in cells and blood vessels which 'stun' the heart, reducing its pumping power (possibly an attempt to protect the heart from overstimulation). Although most patients make a full recovery within days or weeks, around 4 per cent of cases prove fatal.

:: What are the symptoms?

Chest pain and shortness of breath, following the severe emotional or physical stress trigger, are the most common symptoms of Takotsubo syndrome.

"Initial symptoms are similar to those of a heart attack – chest pain, breathlessness or collapse. Call 999 immediately if you or someone you're with experiences these symptoms," McGrath states. Tests will be able to give more of an indication as to what's going on. Takotsubo indicators include electrocardiogram (ECG) abnormalities similar to those of a heart attack but with no evidence of coronary artery disease, and movement abnormalities and ballooning in the left ventricle.

:: Who's at risk?

The majority of people diagnosed – as many as 90 per cent – are post-menopausal women. Experts suspect the number of men diagnosed may be so low because men are more likely to collapse and die from it before reaching hospital, and the true cause of death may not be obvious to the pathologist.

It's thought women are more likely to recover from Takotsubo. It's also suggested that the reason most women diagnosed are post-menopausal is because before menopause, an unknown factor – possibly connected to oestrogen levels – might be providing protection, so they don't develop the condition during the acute stress of childbirth.

:: For further information or support, find the Takotsubo support group on Facebook (

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