THERESA May will travel to Belfast on Monday for what will be her first visit to Northern Ireland since becoming prime minister.
The implications of Brexit are expected to be high on the agenda when she meets first minister Arlene Foster and deputy first minister Martin McGuinness at Stormont Castle.
The visit follows similar meetings in Edinburgh and Cardiff following Ms May's appointment.
A Downing Street spokesman said she would use the trip to "affirm that her government will continue to work with the Northern Ireland Executive, all local political parties and the Irish government to ensure implementation of the Stormont House and Fresh Start agreements, delivering stability in Northern Ireland".
He said she would be fully engaged with Stormont ministers preparing for negotiations on the UK's exit from the European Union.
It is anticipated much of the discussion will surround the future of the border between Northern Ireland and the Republic.
Martin McGuinness said last week he couldn't see how the current free travel arrangements could continue following the UK's departure from the EU.
And Ms May has said it would be "inconceivable" that border controls wouldn't return.
Meanwhile, new Northern Ireland secretary of state James Brokenshire "wants to avoid hard border".
Ms May said she was visiting the north to show, "that I place particular value on the precious bonds between the nations of the United Kingdom".
"I want to assure the people of Northern Ireland that I will lead a government which works for everyone across all parts of the United Kingdom, and that Northern Ireland is a special and valued part of that union," she added.
“I look forward to underlining the government’s commitment to the Belfast Agreement and its institutions, and to working with local parties and the Irish government to fully implement the Stormont House and Fresh Start Agreements. Peace and stability in Northern Ireland will always be of the highest priority for my government."
Although she campaigned for the UK to remain in the EU, Ms May added: "I have been clear that we will make a success of the UK’s departure from the European Union.
That means it must work for Northern Ireland too, including in relation to the border with the Republic. We will engage with all of Northern Ireland’s political parties as we prepare for that negotiation.”
French president Francois Hollande, who was in Dublin for talks with Taoiseach Enda Kenny last week, said the Irish border should be treated as a special case during Brexit negotiations.
And at a meeting of the British-Irish Council on Friday, Mr Kenny said there "will not be a hard border" on the island.
But deputy first minister Martin McGuinness said he couldn't see how the common travel area could be maintained post-Brexit.
